Swelling after Diphenhydramine in dogs

The FDA has received 1,023 reports of swelling in dogs after Diphenhydramine. That is 22% of all reports for this medicine, compared with 2.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,023Reports
55%Marked serious
29%Recovered
8.9%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
544 58%
1–2 days
123 13%
3–7 days
82 8.8%
1–4 weeks
92 9.9%
Over a month
92 9.9%

How the animals did

Recovered
298 29%
Recovered with lasting effects
2 0.2%
Still unwell when reported
440 43%
Died
45 4.4%
Euthanised
46 4.5%
Not known
192 19%

Problems reported at the same time

Age of the animals

Under 1 year
109
1–3 years
371
4–7 years
268
8–11 years
194
12+ years
69

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause swelling in dogs?
1,023 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Swelling with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with swelling