Vomiting after Diphenhydramine in dogs

The FDA has received 1,978 reports of vomiting in dogs after Diphenhydramine. That is 42% of all reports for this medicine, compared with 28% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,978Reports
52%Marked serious
45%Recovered
10%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
965 57%
1–2 days
184 11%
3–7 days
79 4.7%
1–4 weeks
128 7.6%
Over a month
328 19%

How the animals did

Recovered
865 44%
Recovered with lasting effects
19 1.0%
Still unwell when reported
696 35%
Died
109 5.5%
Euthanised
97 4.9%
Not known
192 9.7%

Problems reported at the same time

Age of the animals

Under 1 year
241
1–3 years
725
4–7 years
546
8–11 years
321
12+ years
128

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause vomiting in dogs?
1,978 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with vomiting