Loss of appetite after Diphenhydramine in dogs

The FDA has received 901 reports of loss of appetite in dogs after Diphenhydramine. That is 19% of all reports for this medicine, compared with 8.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

901Reports
63%Marked serious
22%Recovered
18%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
297 39%
1–2 days
151 20%
3–7 days
85 11%
1–4 weeks
93 12%
Over a month
140 18%

How the animals did

Recovered
186 21%
Recovered with lasting effects
16 1.8%
Still unwell when reported
404 45%
Died
55 6.1%
Euthanised
105 12%
Not known
135 15%

Problems reported at the same time

Age of the animals

Under 1 year
80
1–3 years
220
4–7 years
258
8–11 years
215
12+ years
121

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause loss of appetite in dogs?
901 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of appetite with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with loss of appetite