Skin redness after Diphenhydramine in dogs

358 reports to the FDA describe skin redness in dogs given Diphenhydramine. That is 7.6% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

358Reports
55%Marked serious
33%Recovered
5.0%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
155 48%
1–2 days
47 14%
3–7 days
30 9.2%
1–4 weeks
50 15%
Over a month
43 13%

How the animals did

Recovered
114 32%
Recovered with lasting effects
3 0.8%
Still unwell when reported
140 39%
Died
5 1.4%
Euthanised
13 3.6%
Not known
83 23%

Problems reported at the same time

Age of the animals

Under 1 year
17
1–3 years
107
4–7 years
115
8–11 years
91
12+ years
24

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause skin redness in dogs?
358 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with skin redness