Itching after Diphenhydramine in dogs

The FDA has received 553 reports of itching in dogs after Diphenhydramine. That is 12% of all reports for this medicine, compared with 4.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

553Reports
48%Marked serious
35%Recovered
2.7%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
199 45%
1–2 days
53 12%
3–7 days
34 7.6%
1–4 weeks
62 14%
Over a month
99 22%

How the animals did

Recovered
156 28%
Recovered with lasting effects
35 6.3%
Still unwell when reported
212 38%
Died
6 1.1%
Euthanised
9 1.6%
Not known
135 24%

Problems reported at the same time

Age of the animals

Under 1 year
56
1–3 years
183
4–7 years
167
8–11 years
98
12+ years
39

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause itching in dogs?
553 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Itching with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with itching