Fever after Diphenhydramine in dogs

The FDA has received 266 reports of fever in dogs after Diphenhydramine. That is 5.6% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

266Reports
73%Marked serious
21%Recovered
23%Died or euthanised
Same dayTypical onset
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How soon it started

Same day
125 53%
1–2 days
46 19%
3–7 days
18 7.6%
1–4 weeks
15 6.3%
Over a month
34 14%

How the animals did

Recovered
54 20%
Recovered with lasting effects
1 0.4%
Still unwell when reported
118 44%
Died
27 10%
Euthanised
33 12%
Not known
33 12%

Problems reported at the same time

Age of the animals

Under 1 year
31
1–3 years
73
4–7 years
81
8–11 years
57
12+ years
21

About this medicine

Type: medicine.

Questions owners ask

Can Diphenhydramine cause fever in dogs?
266 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within the same day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Fever with similar medicines

All reported side effects of Diphenhydramine in dogs · Medicines most reported with fever