Lethargy after S-adenosylmethionine Silybin in dogs

The FDA has received 33 reports of lethargy in dogs after S-adenosylmethionine Silybin. That is 13% of all reports for this medicine, compared with 11% across reports for all dog medicines.

33Reports
64%Marked serious
12%Recovered
27%Died or euthanised
31 daysTypical onset
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How soon it started

Same day
4 20%
1–2 days
1 5.0%
3–7 days
2 10%
1–4 weeks
3 15%
Over a month
10 50%

How the animals did

Recovered
4 12%
Still unwell when reported
14 42%
Died
2 6.1%
Euthanised
7 21%
Not known
6 18%

Problems reported at the same time

16 48%
14 42%
9 27%
Blood problems
7 21%
Excessive urination
7 21%

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
6
8–11 years
11
12+ years
14

About this medicine

Type: medicine.

Questions owners ask

Can S-adenosylmethionine Silybin cause lethargy in dogs?
33 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of S-adenosylmethionine Silybin in dogs · Medicines most reported with lethargy