Miconazole + Polymyxin B + Prednisolone side effects in dogs

1,090 reports sent to the FDA between 2010 and 2026 involve Miconazole + Polymyxin B + Prednisolone in dogs. The most reported problems were deafness, loss of hearing, impaired hearing. 65% were marked serious, and where it was recorded, signs eased after stopping the medicine in 30% of cases.

1,090Reports
65%Marked serious
42%Only medicine involved
28%Recovered
1.7%Died or euthanised
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About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Most reported side effects

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

Didn't prevent heartworm
9 0.8%
Didn't stop fleas
2 0.2%
Didn't stop worms
2 0.2%

How soon problems started

Same day
134 16%
1–2 days
161 19%
3–7 days
213 25%
1–4 weeks
173 20%
Over a month
183 21%

Time from the first dose to the first sign, where both dates were reported (864 reports).

How the animals did

Recovered
195 18%
Recovered with lasting effects
106 9.7%
Still unwell when reported
374 34%
Died
7 0.6%
Euthanised
12 1.1%
Not known
396 36%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other corticosteroids for dogs