Behaviour change after Miconazole + Polymyxin B + Prednisolone in dogs

The FDA has received 67 reports of behaviour change in dogs after Miconazole + Polymyxin B + Prednisolone. That is 6.1% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

67Reports
75%Marked serious
36%Recovered
0.0%Died or euthanised
4 daysTypical onset
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How soon it started

Same day
10 18%
1–2 days
13 23%
3–7 days
14 25%
1–4 weeks
10 18%
Over a month
9 16%

How the animals did

Recovered
11 16%
Recovered with lasting effects
13 19%
Still unwell when reported
27 40%
Not known
16 24%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
5
4–7 years
11
8–11 years
24
12+ years
23

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Miconazole + Polymyxin B + Prednisolone cause behaviour change in dogs?
67 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 4 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Miconazole + Polymyxin B + Prednisolone in dogs · Medicines most reported with behaviour change