Loss of hearing after Miconazole + Polymyxin B + Prednisolone in dogs

255 reports to the FDA describe loss of hearing in dogs given Miconazole + Polymyxin B + Prednisolone. That is 23% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

255Reports

98%Marked serious

24%Recovered

1.6%Died or euthanised

6 daysTypical onset

How soon it started

Same day

23 10%

1–2 days

48 22%

3–7 days

64 29%

1–4 weeks

42 19%

Over a month

43 20%

How the animals did

Recovered

31 12%

Recovered with lasting effects

31 12%

Still unwell when reported

114 45%

Died

1 0.4%

Euthanised

3 1.2%

Not known

75 29%

Problems reported at the same time

Behaviour change

17 6.7%

Impaired hearing

15 5.9%

Didn't work as expected

12 4.7%

11 4.3%

10 3.9%

9 3.5%

8 3.1%

Ear pain

7 2.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

108

12+ years

106

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Miconazole + Polymyxin B + Prednisolone cause loss of hearing in dogs?: 255 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Loss of hearing with similar medicines

Loss of hearing after Prednisone 43 reports · 0.5% of its reports

All reported side effects of Miconazole + Polymyxin B + Prednisolone in dogs · Medicines most reported with loss of hearing