Didn't work as expected after Miconazole + Polymyxin B + Prednisolone in dogs

The FDA has received 151 reports of didn't work as expected in dogs after Miconazole + Polymyxin B + Prednisolone. That is 14% of all reports for this medicine, compared with 13% across reports for all dog medicines.

151Reports
36%Marked serious
6.0%Recovered
0.0%Died or euthanised
22 daysTypical onset
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How soon it started

Same day
5 5.5%
1–2 days
4 4.4%
3–7 days
13 14%
1–4 weeks
29 32%
Over a month
40 44%

How the animals did

Recovered
4 2.6%
Recovered with lasting effects
5 3.3%
Still unwell when reported
41 27%
Not known
101 67%

Problems reported at the same time

Deafness
20 13%
Drug administration duration too long
20 13%
Loss of hearing
12 7.9%
Ear infection
12 7.9%
Impaired hearing
10 6.6%
Ear discharge
9 6.0%
Partial deafness
9 6.0%
Hearing decreased
9 6.0%

Age of the animals

Under 1 year
7
1–3 years
24
4–7 years
34
8–11 years
50
12+ years
21

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Miconazole + Polymyxin B + Prednisolone cause didn't work as expected in dogs?
151 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 22 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

All reported side effects of Miconazole + Polymyxin B + Prednisolone in dogs · Medicines most reported with didn't work as expected