Didn't work as expected after Prednisolone in dogs

The FDA has received 149 reports of didn't work as expected in dogs after Prednisolone. That is 12% of all reports for this medicine, compared with 13% across reports for all dog medicines.

149Reports
52%Marked serious
5.4%Recovered
14%Died or euthanised
15 daysTypical onset
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How soon it started

Same day
11 12%
1–2 days
10 11%
3–7 days
15 16%
1–4 weeks
23 25%
Over a month
34 37%

How the animals did

Recovered
7 4.7%
Recovered with lasting effects
1 0.7%
Still unwell when reported
79 53%
Died
16 11%
Euthanised
5 3.4%
Not known
41 28%

Problems reported at the same time

Lethargy
22 15%
Death
19 13%
Vomiting
19 13%
Loss of appetite
19 13%
Swelling
18 12%
Liver problems
16 11%
Injection site reaction
15 10%
Skin rash or irritation
13 8.7%

Age of the animals

Under 1 year
5
1–3 years
27
4–7 years
46
8–11 years
49
12+ years
19

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone cause didn't work as expected in dogs?
149 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 15 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

All reported side effects of Prednisolone in dogs · Medicines most reported with didn't work as expected