Injection site reaction after Prednisolone in dogs

64 reports to the FDA describe injection site reaction in dogs given Prednisolone. That is 5.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

64Reports

39%Marked serious

13%Recovered

9.4%Died or euthanised

21 daysTypical onset

How soon it started

Same day

5 8.2%

1–2 days

7 11%

3–7 days

11 18%

1–4 weeks

17 28%

Over a month

21 34%

How the animals did

Recovered

7 11%

Recovered with lasting effects

1 1.6%

Still unwell when reported

31 48%

Died

3 4.7%

Euthanised

3 4.7%

Not known

19 30%

Problems reported at the same time

Loss of appetite

19 30%

Swelling

16 25%

Lethargy

15 23%

Didn't work as expected

15 23%

11 17%

11 17%

10 16%

10 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone cause injection site reaction in dogs?: 64 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 21 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

Injection site reaction after Prednisone 563 reports · 6.3% of its reports
Injection site reaction after Dexamethasone 143 reports · 5.2% of its reports

All reported side effects of Prednisolone in dogs · Medicines most reported with injection site reaction