Injection site reaction after Prednisone in dogs

563 reports to the FDA describe injection site reaction in dogs given Prednisone. That is 6.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

563Reports

40%Marked serious

14%Recovered

8.3%Died or euthanised

10 daysTypical onset

How soon it started

Same day

100 21%

1–2 days

62 13%

3–7 days

55 11%

1–4 weeks

147 30%

Over a month

122 25%

How the animals did

Recovered

75 13%

Recovered with lasting effects

3 0.5%

Still unwell when reported

264 47%

Died

19 3.4%

Euthanised

28 5.0%

Not known

174 31%

Problems reported at the same time

Swelling

226 40%

Didn't work as expected

119 21%

114 20%

99 18%

90 16%

73 13%

68 12%

62 11%

Age of the animals

Under 1 year

1–3 years

176

4–7 years

177

8–11 years

146

12+ years

About this medicine

Prednisone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisone cause injection site reaction in dogs?: 563 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

Injection site reaction after Dexamethasone 143 reports · 5.2% of its reports
Injection site reaction after Prednisolone 64 reports · 5.3% of its reports

All reported side effects of Prednisone in dogs · Medicines most reported with injection site reaction