Behaviour change after Prednisolone + Trimeprazine in dogs

The FDA has received 102 reports of behaviour change in dogs after Prednisolone + Trimeprazine. That is 4.9% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

102Reports
23%Marked serious
25%Recovered
11%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
15 25%
1–2 days
9 15%
3–7 days
7 11%
1–4 weeks
13 21%
Over a month
17 28%

How the animals did

Recovered
22 22%
Recovered with lasting effects
3 2.9%
Still unwell when reported
33 32%
Died
6 5.9%
Euthanised
5 4.9%
Not known
33 32%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
22
4–7 years
34
8–11 years
30
12+ years
9

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause behaviour change in dogs?
102 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with behaviour change