Excessive thirst after Prednisolone + Trimeprazine in dogs

128 reports to the FDA describe excessive thirst in dogs given Prednisolone + Trimeprazine. That is 6.1% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

128Reports
29%Marked serious
14%Recovered
13%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
22 30%
1–2 days
6 8.2%
3–7 days
11 15%
1–4 weeks
22 30%
Over a month
12 16%

How the animals did

Recovered
17 13%
Recovered with lasting effects
1 0.8%
Still unwell when reported
55 43%
Died
9 7.0%
Euthanised
7 5.5%
Not known
39 30%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
18
4–7 years
37
8–11 years
44
12+ years
21

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause excessive thirst in dogs?
128 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive thirst with similar medicines

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with excessive thirst