Diarrhea after Prednisolone + Trimeprazine in dogs

The FDA has received 188 reports of diarrhea in dogs after Prednisolone + Trimeprazine. That is 9.0% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

188Reports
31%Marked serious
22%Recovered
11%Died or euthanised
9 daysTypical onset
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How soon it started

Same day
22 21%
1–2 days
12 11%
3–7 days
15 14%
1–4 weeks
20 19%
Over a month
36 34%

How the animals did

Recovered
36 19%
Recovered with lasting effects
6 3.2%
Still unwell when reported
64 34%
Died
16 8.5%
Euthanised
5 2.7%
Not known
61 32%

Problems reported at the same time

Age of the animals

Under 1 year
8
1–3 years
43
4–7 years
54
8–11 years
54
12+ years
24

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause diarrhea in dogs?
188 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 9 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with diarrhea