Vomiting after Prednisolone + Trimeprazine in dogs

The FDA has received 527 reports of vomiting in dogs after Prednisolone + Trimeprazine. That is 25% of all reports for this medicine, compared with 28% across reports for all dog medicines.

527Reports
20%Marked serious
56%Recovered
7.8%Died or euthanised
24 daysTypical onset
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How soon it started

Same day
82 22%
1–2 days
30 8.2%
3–7 days
31 8.4%
1–4 weeks
52 14%
Over a month
172 47%

How the animals did

Recovered
289 55%
Recovered with lasting effects
6 1.1%
Still unwell when reported
104 20%
Died
23 4.4%
Euthanised
18 3.4%
Not known
87 17%

Problems reported at the same time

Age of the animals

Under 1 year
24
1–3 years
129
4–7 years
176
8–11 years
126
12+ years
62

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause vomiting in dogs?
527 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 24 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with vomiting