Kidney problems after Prednisolone + Trimeprazine in dogs

83 reports to the FDA describe kidney problems in dogs given Prednisolone + Trimeprazine. That is 4.0% of all reports for this medicine, compared with 2.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

83Reports

36%Marked serious

7.2%Recovered

35%Died or euthanised

16 daysTypical onset

How soon it started

Same day

7 17%

1–2 days

3 7.1%

3–7 days

5 12%

1–4 weeks

11 26%

Over a month

16 38%

How the animals did

Recovered

4 4.8%

Recovered with lasting effects

2 2.4%

Still unwell when reported

30 36%

Died

17 20%

Euthanised

12 14%

Not known

18 22%

Problems reported at the same time

46 55%

45 54%

34 41%

32 39%

28 34%

19 23%

17 20%

17 20%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause kidney problems in dogs?: 83 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 16 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Kidney problems with similar medicines

Kidney problems after Prednisone 484 reports · 5.4% of its reports
Kidney problems after Dexamethasone 244 reports · 9.0% of its reports
Kidney problems after Prednisolone 70 reports · 5.8% of its reports

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with kidney problems