Blood problems after Prednisolone + Trimeprazine in dogs

The FDA has received 89 reports of blood problems in dogs after Prednisolone + Trimeprazine. That is 4.3% of all reports for this medicine, compared with 1.8% across reports for all dog medicines, so it is reported unusually often with this medicine.

89Reports

43%Marked serious

9.0%Recovered

30%Died or euthanised

25 daysTypical onset

How soon it started

Same day

8 17%

1–2 days

3 6.3%

3–7 days

5 10%

1–4 weeks

13 27%

Over a month

19 40%

How the animals did

Recovered

6 6.7%

Recovered with lasting effects

2 2.2%

Still unwell when reported

25 28%

Died

21 24%

Euthanised

6 6.7%

Not known

29 33%

Problems reported at the same time

46 52%

33 37%

30 34%

26 29%

19 21%

19 21%

16 18%

14 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause blood problems in dogs?: 89 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 25 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

Blood problems after Prednisone 671 reports · 7.5% of its reports
Blood problems after Dexamethasone 344 reports · 13% of its reports
Blood problems after Prednisolone 130 reports · 11% of its reports

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with blood problems