Lethargy after Prednisolone + Trimeprazine in dogs

318 reports to the FDA describe lethargy in dogs given Prednisolone + Trimeprazine. That is 15% of all reports for this medicine, compared with 11% across reports for all dog medicines.

318Reports
34%Marked serious
26%Recovered
18%Died or euthanised
7 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
49 25%
1–2 days
27 14%
3–7 days
23 12%
1–4 weeks
39 20%
Over a month
57 29%

How the animals did

Recovered
71 22%
Recovered with lasting effects
11 3.5%
Still unwell when reported
95 30%
Died
34 11%
Euthanised
23 7.2%
Not known
84 26%

Problems reported at the same time

Age of the animals

Under 1 year
19
1–3 years
64
4–7 years
89
8–11 years
92
12+ years
47

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause lethargy in dogs?
318 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with lethargy