Fever after Prednisolone + Trimeprazine in dogs

68 reports to the FDA describe fever in dogs given Prednisolone + Trimeprazine. That is 3.2% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

68Reports

37%Marked serious

10%Recovered

21%Died or euthanised

8 daysTypical onset

How soon it started

Same day

10 23%

1–2 days

8 18%

3–7 days

3 6.8%

1–4 weeks

7 16%

Over a month

16 36%

How the animals did

Recovered

7 10%

Still unwell when reported

29 43%

Died

5 7.4%

Euthanised

9 13%

Not known

18 26%

Problems reported at the same time

37 54%

32 47%

24 35%

16 24%

14 21%

Didn't work as expected

13 19%

Blood problems

13 19%

Vomiting

12 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause fever in dogs?: 68 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 8 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Fever with similar medicines

Fever after Prednisone 389 reports · 4.4% of its reports
Fever after Dexamethasone 271 reports · 9.9% of its reports
Fever after Prednisolone 54 reports · 4.5% of its reports

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with fever