Death after Prednisolone + Trimeprazine in dogs

The FDA has received 168 reports of death in dogs after Prednisolone + Trimeprazine. That is 8.0% of all reports for this medicine, compared with 5.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

168Reports
76%Marked serious
0.0%Recovered
98%Died or euthanised
10 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
15 16%
1–2 days
17 18%
3–7 days
13 14%
1–4 weeks
22 23%
Over a month
29 30%

How the animals did

Died
97 58%
Euthanised
68 40%
Not known
3 1.8%

Problems reported at the same time

Age of the animals

Under 1 year
8
1–3 years
14
4–7 years
40
8–11 years
52
12+ years
52

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause death in dogs?
168 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 10 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with death