Breathing problems after Prednisolone + Trimeprazine in dogs

115 reports to the FDA describe breathing problems in dogs given Prednisolone + Trimeprazine. That is 5.5% of all reports for this medicine, compared with 2.7% across reports for all dog medicines, so it is reported unusually often with this medicine.

115Reports
59%Marked serious
16%Recovered
35%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
21 27%
1–2 days
16 21%
3–7 days
9 12%
1–4 weeks
16 21%
Over a month
15 19%

How the animals did

Recovered
17 15%
Recovered with lasting effects
1 0.9%
Still unwell when reported
28 24%
Died
26 23%
Euthanised
14 12%
Not known
29 25%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
17
4–7 years
20
8–11 years
35
12+ years
31

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause breathing problems in dogs?
115 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Breathing problems with similar medicines

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with breathing problems