Prednisolone + Trimeprazine side effects in dogs

2,094 reports sent to the FDA between 1996 and 2026 involve Prednisolone + Trimeprazine in dogs. The most reported problems were vomiting, lethargy, loss of appetite. 25% were marked serious, and where it was recorded, signs eased after stopping the medicine in 100% of cases.

2,094Reports
25%Marked serious
24%Only medicine involved
26%Recovered
8.1%Died or euthanised
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About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Most reported side effects

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

Didn't stop worms
16 0.8%
Didn't stop mites
2 0.1%
Didn't stop ticks
1 0.0%

How soon problems started

Same day
235 18%
1–2 days
114 8.9%
3–7 days
128 10%
1–4 weeks
240 19%
Over a month
561 44%

Time from the first dose to the first sign, where both dates were reported (1,278 reports).

How the animals did

Recovered
509 24%
Recovered with lasting effects
43 2.1%
Still unwell when reported
745 36%
Died
100 4.8%
Euthanised
70 3.3%
Not known
627 30%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other corticosteroids for dogs