Excessive urination after Prednisolone + Trimeprazine in dogs

The FDA has received 110 reports of excessive urination in dogs after Prednisolone + Trimeprazine. That is 5.3% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

110Reports
25%Marked serious
13%Recovered
8.2%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
18 29%
1–2 days
7 11%
3–7 days
8 13%
1–4 weeks
15 24%
Over a month
14 23%

How the animals did

Recovered
14 13%
Still unwell when reported
54 49%
Died
5 4.5%
Euthanised
4 3.6%
Not known
33 30%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
16
4–7 years
41
8–11 years
33
12+ years
13

About this medicine

Prednisolone reduces inflammation and immune activity.

Steroids commonly cause increased thirst, urination and appetite, especially at higher doses.

Questions owners ask

Can Prednisolone + Trimeprazine cause excessive urination in dogs?
110 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive urination with similar medicines

All reported side effects of Prednisolone + Trimeprazine in dogs · Medicines most reported with excessive urination