Ilunocitinib (Zenrelia) side effects in dogs

2,198 reports sent to the FDA between 2022 and 2026 involve Ilunocitinib in dogs. The most reported problems were lethargy, vomiting, liver problems. 23% were marked serious, and where it was recorded, signs eased after stopping the medicine in 100% of cases.

2,198Reports
23%Marked serious
31%Only medicine involved
18%Recovered
6.6%Died or euthanised
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About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Most reported side effects

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

Didn't stop worms
7 0.3%
Didn't stop fleas
6 0.3%
Didn't prevent heartworm
2 0.1%

How soon problems started

Same day
163 8.5%
1–2 days
146 7.6%
3–7 days
122 6.4%
1–4 weeks
343 18%
Over a month
1,140 60%

Time from the first dose to the first sign, where both dates were reported (1,914 reports).

How the animals did

Recovered
396 18%
Still unwell when reported
712 32%
Died
46 2.1%
Euthanised
98 4.5%
Not known
946 43%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other anti-itch medicines for dogs