Didn't work as expected after Ilunocitinib (Zenrelia) in dogs

405 reports to the FDA describe didn't work as expected in dogs given Ilunocitinib. That is 18% of all reports for this medicine, compared with 13% across reports for all dog medicines.

405Reports

12%Marked serious

1.2%Recovered

3.0%Died or euthanised

52 daysTypical onset

How soon it started

Same day

17 4.9%

1–2 days

28 8.0%

3–7 days

20 5.7%

1–4 weeks

53 15%

Over a month

230 66%

How the animals did

Recovered

5 1.2%

Still unwell when reported

89 22%

Died

3 0.7%

Euthanised

9 2.2%

Not known

299 74%

Problems reported at the same time

43 11%

25 6.2%

22 5.4%

22 5.4%

19 4.7%

18 4.4%

18 4.4%

Skin rash or irritation

16 4.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

139

8–11 years

123

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause didn't work as expected in dogs?: 405 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 52 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Oclacitinib (Apoquel) 8,018 reports · 28% of its reports
Didn't work as expected after Cyclosporine (Atopica) 1,099 reports · 7.2% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with didn't work as expected