Diarrhea after Ilunocitinib (Zenrelia) in dogs

The FDA has received 263 reports of diarrhea in dogs after Ilunocitinib. That is 12% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

263Reports
30%Marked serious
25%Recovered
9.9%Died or euthanised
21 daysTypical onset
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How soon it started

Same day
28 12%
1–2 days
36 15%
3–7 days
28 12%
1–4 weeks
44 18%
Over a month
103 43%

How the animals did

Recovered
66 25%
Still unwell when reported
77 29%
Died
10 3.8%
Euthanised
16 6.1%
Not known
94 36%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
46
4–7 years
93
8–11 years
70
12+ years
29

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause diarrhea in dogs?
263 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 21 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

All reported side effects of Ilunocitinib in dogs · Medicines most reported with diarrhea