Death after Ilunocitinib (Zenrelia) in dogs

141 reports to the FDA describe death in dogs given Ilunocitinib. That is 6.4% of all reports for this medicine, compared with 5.2% across reports for all dog medicines.

141Reports

100%Marked serious

0.0%Recovered

100%Died or euthanised

51 daysTypical onset

How soon it started

Same day

2 1.8%

1–2 days

11 10%

3–7 days

10 9.2%

1–4 weeks

18 17%

Over a month

68 62%

How the animals did

Died

43 30%

Euthanised

98 70%

Problems reported at the same time

59 42%

55 39%

48 34%

46 33%

35 25%

31 22%

Abnormal radiograph finding

26 18%

Diarrhea

25 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause death in dogs?: 141 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 51 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

Death after Oclacitinib (Apoquel) 1,431 reports · 4.9% of its reports
Death after Cyclosporine (Atopica) 755 reports · 4.9% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with death