Death after Cyclosporine (Atopica) in dogs

The FDA has received 755 reports of death in dogs after Cyclosporine. That is 4.9% of all reports for this medicine, compared with 5.2% across reports for all dog medicines.

755Reports

55%Marked serious

0.0%Recovered

99%Died or euthanised

17 daysTypical onset

How soon it started

Same day

52 20%

1–2 days

21 7.9%

3–7 days

27 10%

1–4 weeks

64 24%

Over a month

102 38%

How the animals did

Died

474 63%

Euthanised

271 36%

Not known

10 1.3%

Problems reported at the same time

250 33%

242 32%

213 28%

196 26%

166 22%

134 18%

121 16%

108 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

186

8–11 years

302

12+ years

167

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause death in dogs?: 755 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 17 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Death with similar medicines

Death after Oclacitinib (Apoquel) 1,431 reports · 4.9% of its reports
Death after Ilunocitinib (Zenrelia) 141 reports · 6.4% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with death