Liver problems after Cyclosporine (Atopica) in dogs

The FDA has received 1,186 reports of liver problems in dogs after Cyclosporine. That is 7.8% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,186Reports
31%Marked serious
5.1%Recovered
16%Died or euthanised
31 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
28 9.6%
1–2 days
19 6.5%
3–7 days
26 8.9%
1–4 weeks
71 24%
Over a month
147 51%

How the animals did

Recovered
49 4.1%
Recovered with lasting effects
12 1.0%
Still unwell when reported
203 17%
Died
111 9.4%
Euthanised
83 7.0%
Not known
728 61%

Problems reported at the same time

Age of the animals

Under 1 year
7
1–3 years
145
4–7 years
359
8–11 years
455
12+ years
201

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause liver problems in dogs?
1,186 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 31 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

All reported side effects of Cyclosporine in dogs · Medicines most reported with liver problems