Liver problems after Oclacitinib (Apoquel) in dogs

The FDA has received 2,601 reports of liver problems in dogs after Oclacitinib. That is 9.0% of all reports for this medicine, compared with 4.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

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How soon it started

How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause liver problems in dogs?

2,601 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

How soon after a dose was it reported?

In half of the reports with dates, it started within 57 days of the first dose.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Liver problems with similar medicines

• Liver problems after Cyclosporine (Atopica) 1,186 reports · 7.8% of its reports
• Liver problems after Ilunocitinib (Zenrelia) 263 reports · 12% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with liver problems