Diarrhea after Oclacitinib (Apoquel) in dogs

2,589 reports to the FDA describe diarrhea in dogs given Oclacitinib. That is 8.9% of all reports for this medicine, compared with 8.4% across reports for all dog medicines.

2,589Reports
31%Marked serious
26%Recovered
6.7%Died or euthanised
5 daysTypical onset
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How soon it started

Same day
522 25%
1–2 days
374 18%
3–7 days
252 12%
1–4 weeks
331 16%
Over a month
620 30%

How the animals did

Recovered
660 25%
Recovered with lasting effects
5 0.2%
Still unwell when reported
1,289 50%
Died
60 2.3%
Euthanised
113 4.4%
Not known
462 18%

Problems reported at the same time

Age of the animals

Under 1 year
36
1–3 years
599
4–7 years
779
8–11 years
747
12+ years
313

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause diarrhea in dogs?
2,589 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 5 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diarrhea with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with diarrhea