Didn't work as expected after Oclacitinib (Apoquel) in dogs

The FDA has received 8,018 reports of didn't work as expected in dogs after Oclacitinib. That is 28% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported unusually often with this medicine.

8,018Reports

20%Marked serious

4.8%Recovered

1.6%Died or euthanised

31 daysTypical onset

How soon it started

Same day

946 19%

1–2 days

204 4.2%

3–7 days

209 4.3%

1–4 weeks

1,024 21%

Over a month

2,524 51%

How the animals did

Recovered

382 4.8%

Recovered with lasting effects

5 0.1%

Still unwell when reported

5,381 67%

Died

51 0.6%

Euthanised

79 1.0%

Not known

2,120 26%

Problems reported at the same time

Inappropriate schedule of drug administration

526 6.6%

388 4.8%

378 4.7%

362 4.5%

360 4.5%

Skin rash or irritation

342 4.3%

Underdose

336 4.2%

Itching

305 3.8%

Age of the animals

Under 1 year

1–3 years

1,300

4–7 years

2,650

8–11 years

2,265

12+ years

836

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause didn't work as expected in dogs?: 8,018 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Cyclosporine (Atopica) 1,099 reports · 7.2% of its reports
Didn't work as expected after Ilunocitinib (Zenrelia) 405 reports · 18% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with didn't work as expected