Oclacitinib (Apoquel) side effects in dogs

28,968 reports sent to the FDA between 2013 and 2026 involve Oclacitinib in dogs. The most reported problems were vomiting, lethargy, liver problems. 30% were marked serious, and where it was recorded, signs eased after stopping the medicine in 45% of cases.

28,968Reports
30%Marked serious
48%Only medicine involved
16%Recovered
5.0%Died or euthanised
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About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Most reported side effects

4,027 14%
3,089 11%
2,601 9.0%
2,589 8.9%
1,241 4.3%
1,184 4.1%
856 3.0%
824 2.8%
816 2.8%

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

How soon problems started

Same day
4,194 21%
1–2 days
1,798 9.0%
3–7 days
1,542 7.7%
1–4 weeks
3,390 17%
Over a month
8,988 45%

Time from the first dose to the first sign, where both dates were reported (19,912 reports).

How the animals did

Recovered
4,624 16%
Recovered with lasting effects
68 0.2%
Still unwell when reported
17,077 59%
Died
648 2.2%
Euthanised
801 2.8%
Not known
5,750 20%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other anti-itch medicines for dogs