Behaviour change after Oclacitinib (Apoquel) in dogs

The FDA has received 1,391 reports of behaviour change in dogs after Oclacitinib. That is 4.8% of all reports for this medicine, compared with 2.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

1,391Reports
20%Marked serious
26%Recovered
4.9%Died or euthanised
6 daysTypical onset
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How soon it started

Same day
330 30%
1–2 days
150 13%
3–7 days
120 11%
1–4 weeks
175 16%
Over a month
340 30%

How the animals did

Recovered
357 26%
Recovered with lasting effects
4 0.3%
Still unwell when reported
641 46%
Died
22 1.6%
Euthanised
46 3.3%
Not known
321 23%

Problems reported at the same time

Age of the animals

Under 1 year
15
1–3 years
351
4–7 years
491
8–11 years
330
12+ years
119

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause behaviour change in dogs?
1,391 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 6 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Behaviour change with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with behaviour change