Restlessness or agitation after Oclacitinib (Apoquel) in dogs

448 reports to the FDA describe restlessness or agitation in dogs given Oclacitinib. That is 1.5% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

448Reports
28%Marked serious
33%Recovered
6.3%Died or euthanised
2 daysTypical onset
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How soon it started

Same day
142 40%
1–2 days
52 15%
3–7 days
38 11%
1–4 weeks
37 10%
Over a month
85 24%

How the animals did

Recovered
147 33%
Recovered with lasting effects
3 0.7%
Still unwell when reported
189 42%
Died
14 3.1%
Euthanised
14 3.1%
Not known
81 18%

Problems reported at the same time

Age of the animals

Under 1 year
13
1–3 years
94
4–7 years
131
8–11 years
118
12+ years
81

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause restlessness or agitation in dogs?
448 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 2 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with restlessness or agitation