Lethargy after Cyclosporine (Atopica) in dogs

The FDA has received 2,122 reports of lethargy in dogs after Cyclosporine. That is 14% of all reports for this medicine, compared with 11% across reports for all dog medicines.

2,122Reports

29%Marked serious

17%Recovered

11%Died or euthanised

7 daysTypical onset

How soon it started

Same day

175 31%

1–2 days

56 9.8%

3–7 days

56 9.8%

1–4 weeks

94 16%

Over a month

191 33%

How the animals did

Recovered

351 17%

Recovered with lasting effects

19 0.9%

Still unwell when reported

219 10%

Died

144 6.8%

Euthanised

96 4.5%

Not known

1,293 61%

Problems reported at the same time

998 47%

789 37%

592 28%

381 18%

242 11%

192 9.0%

181 8.5%

170 8.0%

Age of the animals

Under 1 year

1–3 years

425

4–7 years

763

8–11 years

663

12+ years

218

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause lethargy in dogs?: 2,122 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 7 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

Lethargy after Oclacitinib (Apoquel) 3,089 reports · 11% of its reports
Lethargy after Ilunocitinib (Zenrelia) 309 reports · 14% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with lethargy