Leucocytosis after Cyclosporine (Atopica) in dogs

The FDA has received 277 reports of leucocytosis in dogs after Cyclosporine. That is 1.8% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

277Reports

31%Marked serious

2.5%Recovered

36%Died or euthanised

19 daysTypical onset

How soon it started

Same day

4 5.7%

1–2 days

5 7.1%

3–7 days

9 13%

1–4 weeks

25 36%

Over a month

27 39%

How the animals did

Recovered

7 2.5%

Still unwell when reported

25 9.0%

Died

56 20%

Euthanised

45 16%

Not known

144 52%

Problems reported at the same time

160 58%

140 51%

135 49%

124 45%

116 42%

107 39%

103 37%

82 30%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause leucocytosis in dogs?: 277 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 19 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

Leucocytosis after Oclacitinib (Apoquel) 359 reports · 1.2% of its reports
Leucocytosis after Ilunocitinib (Zenrelia) 24 reports · 1.1% of its reports

All reported side effects of Cyclosporine in dogs · Medicines most reported with leucocytosis