Leucocytosis after Oclacitinib (Apoquel) in dogs

The FDA has received 359 reports of leucocytosis in dogs after Oclacitinib. That is 1.2% of all reports for this medicine, compared with 1.0% across reports for all dog medicines.

359Reports

61%Marked serious

5.6%Recovered

23%Died or euthanised

23 daysTypical onset

How soon it started

Same day

41 16%

1–2 days

24 9.4%

3–7 days

22 8.7%

1–4 weeks

49 19%

Over a month

118 46%

How the animals did

Recovered

19 5.3%

Recovered with lasting effects

1 0.3%

Still unwell when reported

225 63%

Died

20 5.6%

Euthanised

62 17%

Not known

32 8.9%

Problems reported at the same time

155 43%

151 42%

142 40%

138 38%

102 28%

100 28%

82 23%

77 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

114

8–11 years

126

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause leucocytosis in dogs?: 359 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 23 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucocytosis with similar medicines

Leucocytosis after Cyclosporine (Atopica) 277 reports · 1.8% of its reports
Leucocytosis after Ilunocitinib (Zenrelia) 24 reports · 1.1% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with leucocytosis