Neutrophilia after Oclacitinib (Apoquel) in dogs

The FDA has received 264 reports of neutrophilia in dogs after Oclacitinib. That is 0.9% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

264Reports

62%Marked serious

6.1%Recovered

22%Died or euthanised

31 daysTypical onset

How soon it started

Same day

25 14%

1–2 days

18 9.9%

3–7 days

13 7.2%

1–4 weeks

33 18%

Over a month

92 51%

How the animals did

Recovered

15 5.7%

Recovered with lasting effects

1 0.4%

Still unwell when reported

158 60%

Died

17 6.4%

Euthanised

40 15%

Not known

33 13%

Problems reported at the same time

138 52%

127 48%

126 48%

116 44%

82 31%

71 27%

64 24%

62 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause neutrophilia in dogs?: 264 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutrophilia with similar medicines

Neutrophilia after Cyclosporine (Atopica) 173 reports · 1.1% of its reports
Neutrophilia after Ilunocitinib (Zenrelia) 47 reports · 2.1% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with neutrophilia