Itching after Ilunocitinib (Zenrelia) in dogs

175 reports to the FDA describe itching in dogs given Ilunocitinib. That is 8.0% of all reports for this medicine, compared with 4.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

175Reports

23%Marked serious

15%Recovered

5.7%Died or euthanised

53 daysTypical onset

How soon it started

Same day

14 9.0%

1–2 days

9 5.8%

3–7 days

9 5.8%

1–4 weeks

24 15%

Over a month

99 64%

How the animals did

Recovered

27 15%

Still unwell when reported

78 45%

Died

3 1.7%

Euthanised

7 4.0%

Not known

60 34%

Problems reported at the same time

Didn't work as expected

43 25%

Lethargy

30 17%

Skin rash or irritation

26 15%

25 14%

20 11%

20 11%

19 11%

18 10%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause itching in dogs?: 175 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 53 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Itching with similar medicines

Itching after Oclacitinib (Apoquel) 1,184 reports · 4.1% of its reports
Itching after Cyclosporine (Atopica) 1,459 reports · 9.5% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with itching