Skin redness after Ilunocitinib (Zenrelia) in dogs

The FDA has received 55 reports of skin redness in dogs after Ilunocitinib. That is 2.5% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

55Reports

47%Marked serious

9.1%Recovered

5.5%Died or euthanised

85 daysTypical onset

How soon it started

Same day

4 8.9%

1–2 days

3 6.7%

3–7 days

1 2.2%

1–4 weeks

5 11%

Over a month

32 71%

How the animals did

Recovered

5 9.1%

Still unwell when reported

29 53%

Died

1 1.8%

Euthanised

2 3.6%

Not known

18 33%

Problems reported at the same time

Itching

18 33%

Didn't work as expected

15 27%

14 25%

14 25%

13 24%

10 18%

Skin rash or irritation

10 18%

Neutropenia

10 18%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause skin redness in dogs?: 55 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 85 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin redness with similar medicines

Skin redness after Oclacitinib (Apoquel) 519 reports · 1.8% of its reports
Skin redness after Cyclosporine (Atopica) 229 reports · 1.5% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with skin redness