Ivermectin + Praziquantel side effects in dogs

204 reports sent to the FDA between 2003 and 2026 involve Ivermectin + Praziquantel in dogs. The most reported problems were eye or vision problems, wobbliness (ataxia), tremors. 28% were marked serious.

204Reports
28%Marked serious
93%Only medicine involved
2.9%Recovered
7.4%Died or euthanised
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Most reported side effects

61 30%
40 20%
35 17%
22 11%
Drooling
19 9.3%
Loss of appetite
13 6.4%
Tachycardia
12 5.9%
Disorientation
12 5.9%
Labeled drug-species interaction
12 5.9%
Staggering
10 4.9%
Neurological signs
9 4.4%
Unresponsive
9 4.4%

Share = percentage of this medicine's reports that mention the problem. One report can list several problems.

Reports that it didn't work

Some reports are about the medicine not working (for example a dog still getting fleas or heartworm), not about a side effect.

Didn't prevent heartworm
6 2.9%
Didn't stop fleas
3 1.5%
Didn't work as expected
1 0.5%

How soon problems started

Same day
36 69%
1–2 days
13 25%
3–7 days
0 0.0%
1–4 weeks
0 0.0%
Over a month
3 5.8%

Time from the first dose to the first sign, where both dates were reported (52 reports).

How the animals did

Recovered
5 2.5%
Recovered with lasting effects
1 0.5%
Still unwell when reported
8 3.9%
Died
15 7.4%
Not known
175 86%

Breeds named most often

Popular breeds appear more often because there are more of them.

Other macrocyclic lactone (heartworm and parasite prevention)s for dogs