Tremors after Ivermectin + Praziquantel in dogs

61 reports to the FDA describe tremors in dogs given Ivermectin + Praziquantel. That is 30% of all reports for this medicine, compared with 3.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

61Reports

36%Marked serious

3.3%Recovered

11%Died or euthanised

Same dayTypical onset

How soon it started

Same day

16 89%

1–2 days

2 11%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

0 0.0%

How the animals did

Recovered

2 3.3%

Still unwell when reported

6 9.8%

Died

7 11%

Not known

46 75%

Problems reported at the same time

Eye or vision problems

33 54%

Wobbliness (ataxia)

25 41%

Vomiting

13 21%

Drooling

13 21%

Accidental exposure

13 21%

Lethargy

12 20%

Seizures

9 15%

Death

7 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel cause tremors in dogs?: 61 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tremors with similar medicines

Tremors after Ivermectin + Pyrantel (Heartgard Plus) 2,169 reports · 1.5% of its reports
Tremors after Milbemycin Oxime + Spinosad (Trifexis) 5,684 reports · 4.4% of its reports
Tremors after Moxidectin (ProHeart 6) 1,208 reports · 2.4% of its reports
Tremors after Milbemycin Oxime + Praziquantel (Interceptor Plus) 766 reports · 2.4% of its reports
Tremors after Milbemycin Oxime (Interceptor) 729 reports · 2.4% of its reports
Tremors after Selamectin (Revolution) 984 reports · 3.3% of its reports
Tremors after Ivermectin (Heartgard) 959 reports · 8.0% of its reports
Tremors after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 245 reports · 2.9% of its reports
Tremors after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 56 reports · 4.8% of its reports
Tremors after Moxidectin + Praziquantel 27 reports · 36% of its reports

All reported side effects of Ivermectin + Praziquantel in dogs · Medicines most reported with tremors