Accidental exposure after Ivermectin + Praziquantel in dogs

The FDA has received 51 reports of accidental exposure in dogs after Ivermectin + Praziquantel. That is 25% of all reports for this medicine, compared with 1.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

51Reports

16%Marked serious

2.0%Recovered

2.0%Died or euthanised

–Typical onset

How the animals did

Recovered

1 2.0%

Still unwell when reported

1 2.0%

Died

1 2.0%

Not known

48 94%

Problems reported at the same time

Eye or vision problems

29 57%

21 41%

14 27%

13 25%

8 16%

Drooling

5 9.8%

Neurological signs

4 7.8%

Loss of appetite

4 7.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel cause accidental exposure in dogs?: 51 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Accidental exposure with similar medicines

Accidental exposure after Ivermectin + Pyrantel (Heartgard Plus) 583 reports · 0.4% of its reports
Accidental exposure after Milbemycin Oxime + Spinosad (Trifexis) 1,509 reports · 1.2% of its reports
Accidental exposure after Moxidectin (ProHeart 6) 221 reports · 0.4% of its reports
Accidental exposure after Milbemycin Oxime + Praziquantel (Interceptor Plus) 86 reports · 0.3% of its reports
Accidental exposure after Milbemycin Oxime (Interceptor) 411 reports · 1.4% of its reports
Accidental exposure after Selamectin (Revolution) 311 reports · 1.1% of its reports
Accidental exposure after Ivermectin (Heartgard) 434 reports · 3.6% of its reports
Accidental exposure after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 118 reports · 1.4% of its reports
Accidental exposure after Eprinomectin 57 reports · 54% of its reports
Accidental exposure after Moxidectin + Praziquantel 22 reports · 29% of its reports

All reported side effects of Ivermectin + Praziquantel in dogs · Medicines most reported with accidental exposure