Accidental exposure after Moxidectin (ProHeart 6) in dogs

The FDA has received 221 reports of accidental exposure in dogs after Moxidectin. That is 0.4% of all reports for this medicine, compared with 1.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

221Reports

7.2%Marked serious

5.0%Recovered

9.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

11 38%

1–2 days

5 17%

3–7 days

2 6.9%

1–4 weeks

2 6.9%

Over a month

9 31%

How the animals did

Recovered

11 5.0%

Still unwell when reported

22 10.0%

Died

20 9.0%

Not known

168 76%

Problems reported at the same time

98 44%

50 23%

38 17%

36 16%

34 15%

Eye or vision problems

26 12%

Recumbency

23 10%

Death

19 8.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause accidental exposure in dogs?: 221 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Accidental exposure with similar medicines

Accidental exposure after Ivermectin + Pyrantel (Heartgard Plus) 583 reports · 0.4% of its reports
Accidental exposure after Milbemycin Oxime + Spinosad (Trifexis) 1,509 reports · 1.2% of its reports
Accidental exposure after Milbemycin Oxime + Praziquantel (Interceptor Plus) 86 reports · 0.3% of its reports
Accidental exposure after Milbemycin Oxime (Interceptor) 411 reports · 1.4% of its reports
Accidental exposure after Selamectin (Revolution) 311 reports · 1.1% of its reports
Accidental exposure after Ivermectin (Heartgard) 434 reports · 3.6% of its reports
Accidental exposure after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 118 reports · 1.4% of its reports
Accidental exposure after Ivermectin + Praziquantel 51 reports · 25% of its reports
Accidental exposure after Eprinomectin 57 reports · 54% of its reports
Accidental exposure after Moxidectin + Praziquantel 22 reports · 29% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with accidental exposure