Accidental exposure after Moxidectin + Praziquantel in dogs

The FDA has received 22 reports of accidental exposure in dogs after Moxidectin + Praziquantel. That is 29% of all reports for this medicine, compared with 1.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

22Reports

9.1%Marked serious

0.0%Recovered

14%Died or euthanised

–Typical onset

How the animals did

Still unwell when reported

1 4.5%

Died

3 14%

Not known

18 82%

Problems reported at the same time

Wobbliness (ataxia)

12 55%

Tremors

8 36%

Drooling

7 32%

Lethargy

7 32%

Seizures

4 18%

Loss of consciousness

3 14%

Recumbency

3 14%

Vomiting

3 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Praziquantel cause accidental exposure in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Accidental exposure with similar medicines

Accidental exposure after Ivermectin + Pyrantel (Heartgard Plus) 583 reports · 0.4% of its reports
Accidental exposure after Milbemycin Oxime + Spinosad (Trifexis) 1,509 reports · 1.2% of its reports
Accidental exposure after Moxidectin (ProHeart 6) 221 reports · 0.4% of its reports
Accidental exposure after Milbemycin Oxime + Praziquantel (Interceptor Plus) 86 reports · 0.3% of its reports
Accidental exposure after Milbemycin Oxime (Interceptor) 411 reports · 1.4% of its reports
Accidental exposure after Selamectin (Revolution) 311 reports · 1.1% of its reports
Accidental exposure after Ivermectin (Heartgard) 434 reports · 3.6% of its reports
Accidental exposure after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 118 reports · 1.4% of its reports
Accidental exposure after Ivermectin + Praziquantel 51 reports · 25% of its reports
Accidental exposure after Eprinomectin 57 reports · 54% of its reports

All reported side effects of Moxidectin + Praziquantel in dogs · Medicines most reported with accidental exposure