Wobbliness (ataxia) after Moxidectin + Praziquantel in dogs

40 reports to the FDA describe wobbliness (ataxia) in dogs given Moxidectin + Praziquantel. That is 53% of all reports for this medicine, compared with 2.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

40Reports

18%Marked serious

2.5%Recovered

5.0%Died or euthanised

1 daysTypical onset

How soon it started

Same day

6 50%

1–2 days

4 33%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

2 17%

How the animals did

Recovered

1 2.5%

Still unwell when reported

10 25%

Died

2 5.0%

Not known

27 68%

Problems reported at the same time

Tremors

15 38%

Drooling

12 30%

Accidental exposure

12 30%

Lethargy

9 23%

Vomiting

8 20%

Breathing problems

6 15%

Fever

5 13%

Disorientation

3 7.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs). Praziquantel treats tapeworms.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin + Praziquantel cause wobbliness (ataxia) in dogs?: 40 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

Wobbliness (ataxia) after Ivermectin + Pyrantel (Heartgard Plus) 1,346 reports · 0.9% of its reports
Wobbliness (ataxia) after Milbemycin Oxime + Spinosad (Trifexis) 2,821 reports · 2.2% of its reports
Wobbliness (ataxia) after Moxidectin (ProHeart 6) 1,147 reports · 2.3% of its reports
Wobbliness (ataxia) after Milbemycin Oxime + Praziquantel (Interceptor Plus) 533 reports · 1.7% of its reports
Wobbliness (ataxia) after Milbemycin Oxime (Interceptor) 712 reports · 2.4% of its reports
Wobbliness (ataxia) after Selamectin (Revolution) 622 reports · 2.1% of its reports
Wobbliness (ataxia) after Ivermectin (Heartgard) 1,237 reports · 10% of its reports
Wobbliness (ataxia) after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 119 reports · 1.4% of its reports
Wobbliness (ataxia) after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 24 reports · 2.1% of its reports
Wobbliness (ataxia) after Ivermectin + Praziquantel 81 reports · 40% of its reports

All reported side effects of Moxidectin + Praziquantel in dogs · Medicines most reported with wobbliness (ataxia)